Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes

Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes

Blog Article

Ketones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis.Transition metal catalysis has proven to be an effective method for synthesizing ketones.However, the Keyboard/Mouse Combos scope of these substrates remains relatively limited, particularly due to their incompatibility with sensitive functional groups.Herein, we report a Ni-catalyzed three-component 1,2-carboacylation of alkenes, which activates secondary/tertiary alkyl bromides.

This method offers significant advantages: simplicity of operation, ready availability of substrates, and broad substrate applicability.A series of experimental studies have helped clarify the key mechanistic pathways Girls Slippers involved in this cascade reaction.